The A330-300 became Northwest's transatlantic flagship aircraft, gradually replacing Douglas DC-10-30s. The last Northwest DC-10 ended international service on October 29, 2006, and retired from domestic service on January 8, 2007.

The A330's fuel efficiency allowed Northwest to increase transatlantic service by 12% from 2000-2007, but use almost 30% less fuel. Northwest CEO Doug Steenland said the fuel-efficient A330 fleet was part of the "greening of Northwest Airlines." The A330 was much quieter and 35% more efficient than the DC-10 aircraft it replaced.

In October 2007, Northwest received its 32nd A330 aircraft, making it the largest A330 operator in the world. Northwest now had the youngest international fleet of any North American airline, and the youngest transatlantic fleet of any North American or European carrier.

Ship 3322 (MSN 1627) was the first new Airbus A330-300 aircraft purchased by Delta following the 2008 merger with Northwest Airlines, and one of ten new A330-300s scheduled to enter Delta's fleet by 2017.

The new A330-300s are 15 to 25 percent more fuel efficient per seat than the Boeing 767-300s and Boeing 747-400s they replaced. The A330 operate primarily on Delta Atlantic and Pacific long-range routes, as well as provide Delta's network with more flexibility to optimally match capacity with demand. The aircraft is powered by General Electric CF6-80E1 engines.

The Airbus A330-300 features 34 full flat-bed seats with direct aisle access in Delta One, 32 extra-legroom seats in Delta Comfort+ and 227 Main Cabin seats. Delta customers enjoy access to satellite in-flight Wi-Fi featuring the Delta Studio library of free streaming programming as well as more than 1,000 on-demand movies, television shows and music on large, high-definition seatback monitors. Customers also benefit from modern interiors with LED lighting and extra-capacity overhead bins.

On November 19, 2014, Delta became the launch customer for the extended fuselage Airbus A330-900neo with an order for 25. In November 2018, Delta increased its order to 35. 

The aircraft was ordered for Delta's medium-haul trans-Atlantic routes and select routes between the West Coast and Asia, replacing older Boeing 767-300ERs. New, more efficient engines allowed for a longer flying range of 7,200 miles than Delta's standard A330-300 aircraft.

Delta took delivery of its first A330-900neo, Ship 3401, on May 23, 2019. In an environmental partnership with Airbus, Delta flew the delivery flight using jet fuel blended with non-petroleum synthetic fuel.

Service began on July 10, 2019, with flight DL589 from Seattle to Shanghai. Flights connecting Seattle with Seoul started October 1 and Tokyo-Narita on October 27, 2019. 

Highlights:

• Delta was the first U.S. airline to operate the A330-900neo.
• First new widebody delivery to feature four Delta seat experiences: Delta One Suite (29 seats), Delta Premium Select (28), Delta Comfort+ (56) and Main Cabin (168).
• First Delta aircraft delivered with memory foam cushioned seats throughout the aircraft.
• First widebody aircraft featuring a new wireless in-flight entertainment system from Delta Flight Products.
• Rolls-Royce Trent 7000 engines produce a 25 percent lower fuel burn than previous generation aircraft.